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In the present study, we observed that socially isolated mice show shorter sleeping time than the group-housed mice and that the benzodia... Read More

YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep... Read More

Animals were housed either in social isolation (1 mouse per cage) or in social groups (5 mice per cage) for 9 – 12 weeks prior to t... Read More

YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sle... Read More

YKS has been demonstrated to improve behavioral and　psychological symptoms of　dementia (BPSD), such　as hallucinations, agitation, and irr... Read More

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Abstract. In the present study, we investigated the effect of the Kampo medicme Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-mduced sleeping time in socally isolated mice without affecting pentobarbtal sleep In group-housed mice. The prolongation of sleeping time by YKS was reversed by bcucul- Ine (3 mg/kg, ip.) and flumazenil (3 mg/kg, ip.), but not WAY100635. These findings suggest that the でABA。 - benzodiazepine receptor complex, but not 5-HTi。 receptors, 1s involved in the reversal effect of YKS on the decrease of pentobarbital sleep by socal isolation. eyの7の: sleep, soclal isolation, Yokukansan YKS), a Kampo medicine, is widely nia, Irritability, and screamng attacks. monstrated to improve behavioral and nptoms of dementia (BPSD), such as ltation, and irritability, in a randomized er, YKS improves sleep disturbance im ぐT) /う) 丁hnns 1c にak 人haf VIEKS bital-mduced sleep in group-housed and socially isolated mice. In addition, the 7?-aminobutyric acld。 (GABAA) benzodiazepine receptor complex is involved in the de- crease Of pentobarbital sleep by soclal isolation (7). Furthermore, social isolation influences でABAAreceptor subunit expression and postsynaptic serotonniA (5-HT」A) eneTfnr hinrhino in ncre (CS 9O) 征haerefnTe te alcn =eマamnュ=

Galton-Watson分枝過程とランダムウォークは同じものと捉えてよいのでしょうか？ 知ってる方よろしくお願いします。

この化合物の立体異性体を求める過程を教えてください。

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