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Abstract. In the present study, we investigated the effect of the Kampo medicme Yokukansan
(YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated
mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged
the pentobarbital-mduced sleeping time in socally isolated mice without affecting pentobarbtal
sleep In group-housed mice. The prolongation of sleeping time by YKS was reversed by bcucul-
Ine (3 mg/kg, ip.) and flumazenil (3 mg/kg, ip.), but not WAY100635. These findings suggest
that the でABA。 - benzodiazepine receptor complex, but not 5-HTi。 receptors, 1s involved in the
reversal effect of YKS on the decrease of pentobarbital sleep by socal isolation.
eyの7の: sleep, soclal isolation, Yokukansan
YKS), a Kampo medicine, is widely
nia, Irritability, and screamng attacks.
monstrated to improve behavioral and
nptoms of dementia (BPSD), such as
ltation, and irritability, in a randomized
er, YKS improves sleep disturbance im
ぐT) /う) 丁hnns 1c にak 人haf VIEKS
bital-mduced sleep in group-housed and socially isolated
mice. In addition, the 7?-aminobutyric acld。 (GABAA)
benzodiazepine receptor complex is involved in the de-
crease Of pentobarbital sleep by soclal isolation (7).
Furthermore, social isolation influences でABAAreceptor
subunit expression and postsynaptic serotonniA (5-HT」A)
eneTfnr hinrhino in ncre (CS 9O) 征haerefnTe te alcn =eマamnュ=
