659 Every biologist soon wanted a favorite gene punched out, and a
handful of companies quickly began competing with places such as the
Jackson Laboratory in Bar Harbor, Maine, to provide knockout strains
to drug companies and academic labs/To date, researchers have knocked
out at least 11,000 genes in mice, observing what goes wrong in
70 development or adulthood and thereby gaining a sense of what the gene
does. By deactivating specific genes this way, for example, Capecchi
and his colleagues went on to identify ones that shape limbs, organs, and
the overall mammalian body plan. Both Smithies and Evans developed
mice lacking the cystic fibrosis gene one of many knockout mouse
75 strains created to mimic a human illness. Indeed, there is now a
worldwide effort to knock out every mouse gene.
(Science, October 12, 2007 より引用 一部改変)
(筑波大・後期)
*in fact : 実は、それどころか cystic fibrosis: 嚢胞性線維症
を作
E
