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薬学 大学生・専門学校生・社会人

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2020年度 生物薬剤学本試験問題 試験日 6月23日 試験時間 60分 学籍番号 氏名 以下の問題を読んで、 問いに対する解答を解答用紙に記入せよ。 * 解答に単位を付けること 問題1:催眠・鎮静・抗けいれん効果が知られているフェノバルビタールは弱酸性薬物であ り、そのpKa は 7.3 分子量は232 である。 pH 6.3 の緩衝液を用いて、薬物の飽和溶液を 作製し、濃度を測定すると、2.0mg/mLであった。 また、みかけの分配係数(クロロホルム /緩衝液)を測定すると、 3.0 となった。 以下の問いに答えよ。 ただし、 分子形とイオン形 の割合は Henderson Hasselbalch の式に従い、容器等にこの薬物は吸着しないものとする。 1. この緩衝液中での、薬物の① 分子形分率および ② イオン形分率をそれぞれ求めよ。 2.この緩衝液中での、薬物の① 分子形濃度および ② イオン形濃度をそれぞれ求めよ。 3. この緩衝液とクロロホルムを同量混合し、平衡に達した後の緩衝液中薬物濃度を求めよ。 4. 真の分配係数 (クロロホルム/緩衝液)を計算せよ。 5. 緩衝液を pH7.3にした場合、 pH6.3 と比べ、見かけの分配係数はどちらが大きいと考え られるか。 ①緩衝液のpHを解答欄に書け。 また pH7.3 の時の②見かけの分配係数を 求めよ。 6. 緩衝液をpH7.3 にした時の真の分配係数は、 pH6.3 の時と比べて何倍になるか。 7. この薬物 400mg を静脈内投与した後、 血漿中濃度を測定すると 10 μg/mL だった。 分布容積(L) を求めよ。 8. 分布容積の結果から、この薬物は体液中どこまで分布していると考えられるか。 以下か ら選び記号で答えよ。 (A: 血漿内にとどまる B: 細胞外液まで C: 全体液中) 9. この薬物は複数の薬物と相互作用を引き起こすことが知られている。 この相互作用が 起こる原因として、この薬物によって①どのような代謝酵素が②誘導または阻害するか らなのか答えよ。 10. この薬物の体内からの消失速度を求めたところ、血漿中濃度が 10μg/mL のとき、 2.4 mg/h であった。 全身クリアランス (mL/h)を求めよ。 ただし、この薬物の消失は 1次速度に従うものとする。 11. この薬物の尿中排泄を考えたとき、 尿のpHがアルカリ性になると、 排泄速度は A : 増加するか、 B: 減少するか、 C: 変化しないか、 どれか。 理由とともに示せ。 12. この薬物が過量投与され、 血中濃度が 50 μg/mL を越えた場合、 中毒症状・昏睡を 起こす可能性がある。 このような時、 この薬物の尿中排泄を促進するために投与すべき 薬物名 (化学式も可)を1つ示せ。 (ヒント:尿のpHを変化させる物質は?) 13. この薬物には、 プロドラッグが存在する。 そのプロドラッグの名称を以下から選び、 記号で答えよ。 (A : アミトリプチリン B: プリミドン C: ジアゼパム D: フェナセチン)

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TOEIC・英語 大学生・専門学校生・社会人

英語の問題です。 この答えが分かる方いらっしゃいますか?

9. Though himself. statesman, James Polk was unusually successful in accomplishing his goals during his term. (A) not yla w op at odw oldiassi oimonoe ai ginimbno JisM al 13. In contrast to popular opinion, measures of intelligence have. teliable predictors of future success. -imaginative U ada t an inola Isoioiso ors 3) never been M. (B) without an (C) he was not (B) not any (C) no TI ni 2stsa2 (D) seldom (D) was not an ntaib gaol 3a uinillida ods daidw. at alolbabus( 14, The name "porpoise" sometimes 10. Blends of spices have been created by spice manufacturers to make the art of scasoning to some members of the dolphin family, (A) it is extended ons Jbodai(A) a quick and casy one ailavon usolnsas (B) is an extension *A (C) extended pollusH (D) is extended (B) casy and quick a one (C) a quick one and easyon Issiufo adh (D) one casy and quick ot 11. During nothe 1950。ch adol bag-baxits5. In old age, the immune system proponents of inguistic relativity believed that - to language or representational functioning. graduaily becomes less resistant to viral fangal, and s od thought- (A) infection by bacteria (A) can reduceitomootains ae 2s oibilids aii (B) bacteria's infection e (B) could be reduced (C) reduces (D) reducing e aoiseniaimbs zot sldienogesn al uo smezqu2 arb 3o soitaui 3oid ad.S 12.- (C) bacterial infection ida lanigho ms a (D) infectious bacteria A that nearly all households will haye broadband internet by the vear baale yiwn olo lo dsso 2015. (A) ExpectingLni s2osh os tiorual atgsimue asar ads gorW.ES (B) Many expecting (C) In expectation nwob" sd oa biea ymaqmoo adt atenoyitisamos (D) It is expected A h o obla gaoxworb po pexdmh ow nomwal nmissmA yhsbM as A

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TOEIC・英語 大学生・専門学校生・社会人

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未習長文E インフォメーションリスト untrustworthy profession psychology not able to be relied on as honest or truthful ajob that needsa high level of education and training the study of the mind and how it influences people's behavior often rewards society often understands and accepts lying. S0ociety deception. 0cupation |confess a job or profession to admit, especially to the police, that you have done something wrong or illegal Something successful or impressive that is achieved after a lot of effort and hard work someone who trains a person or team in a sport a manager in an organization or company who helps make important decisions to express your disapproval of someone or something, or to talk about their faults accomplishment coach executive criticize at times sometimes%;B on occasions an idea or story that many people believe, but which is not myth true exaggerate to make something seem better, larger, worse etc. than it really is to not include someone or something behavior in which you deceive or cheat people relating to feelings of love or a loving relationships intended to make someone believe something that is not leave out dishonesty romantic deceptive ture Conversation an informal talk in which people exchange news, feelings, and thoughts something that is very bad or a failure, especially when this is very annoying or disappointing not often; seldom disaster seldom

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TOEIC・英語 大学生・専門学校生・社会人

このプリントの日本語訳を教えてください

未習長文D インフォメーションリスト |adopt medicine to start to deal with or think about something ina particular wav 1. a substance used for treating an illness, especially a liquid you drink the treatment and study of illnesses and injuries 2. to depend on someone to provide help, advice, etc. to think that you are better than someone else, for example because you are more sucessful, or of a higher social lass than they are fair and sensible look to look down on reasonable can/could afford people were better off using It would be better for people to use traditional traditional medicine rather than medicine rather than having no medicine. no medicine at all. establish to have enough money to buy or pay for something to start a company, organization, system, etc. that is intended to exist or continue for a long time 1.(n) the work of a doctor or lawyer, or the place where they work 2.(v) to use a particular method or custom the act of starting an organization, relationship, or system the process or fact of being received as adequate, valid, or suitable practice establishment acceptance a small creature such as a fly or ant, that has six legs, and sometimes wings anything that is living, such as an animal, fish, or insect, but not a plant a plant like a small onion, used in cooking to give a strong insect creature garlic taste bacteria very small living things, some of which causes illness or disease a chemical substance found in your blood. cholesterol in your blood may cause heart disease. to absorb something into the body, for example by breathing or swallowing a scientific test done to find out how something reacts under certain conditions, or to find out if a particular idea is true (v) to make something less dense or numerous look at something again closely if someone has a stroke, an artery (tube carrying blood) in their brain suddenly bursts or becomes blocked, so that they may not real or not made of natural things but made to be like something that is real or natural a substance used in chemistary or produced by achemical cholesterol Too much take in experiment thin take a second look at stroke die or be unable to use some muscles artificial chemical process to help to make something happen to help to make something happen Contribute think highly of o place Migh value on

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TOEIC・英語 大学生・専門学校生・社会人

このプリントの日本語訳を教えてください

未習長文B インフォメーションリスト Your conclusion varies from mine. Vary the ability to know something by using your feelings rather than considering the facts the ability to think in a logical way and understand things, especially at an advanced level intuition intellect represent Dots on the map represent towns. adaptable easily adaptable to individual needs symbolize Orange symbolizes pride. ambition an ambition for success primitive a primitive tribe fertile (of land or soil) that plants grow well in a ceremony that is always performed in the same way, in order to mark an important religious or social occasion a ceremony performed by a particular group of people, often for religious ritual rite purposes 未習長文C インフォメーションリスト depression certainly stay close allow feel depression on hearing the news Certainly well consider your suggestion. Stay close to me. allow him to go out need a need to be loved self-esteem a man with low self-esteem attract attract his attention Consider the problem seriously win popularity Compare Japan to China a comparison of temperature in Osaka and Hokkaido Iwalk with my pet to motivate myself to lose weight. Her novels tend to be boring. Iwould rather walk than go by car. Consider popularity Compare Comparison motivate tend to WOuld rather Athan B make a good impression on him Drinking is bad for your health, but smoking is worse. This tool is valuable for sleeping in a forest. I keep in touch with my parents by E-mail To decrease your stress at work, avoid wasting time. post pictures on twitter impression Worse valuable keep in touch with decrease post

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TOEIC・英語 大学生・専門学校生・社会人

このプリントの日本語訳を教えてください

ER 試験に出る単語など 未習長文A インフォメーションリスト 単語など 定義·例文情報 現代美時信: Contemporary | contemporary art works be pleased to Japan Museumis pleased to present 'Sōsaku hanga. exhibition Collection of things, for example works of art, that are shown to the public. feature The hotel features a magnificent ocean view. Lacquerware are objects decoratively covered with lacquer. The work of a joiner. lacquerware joinery Coat a metal coated with gold Lacquer sap has been used by humans from long time ago. It was treated as a luxury item. sap resistant heat-resistant moisture small amount of water that are present in the air. decorative a decorative design sprinkle Silver powder is sprinkled on its surface. appear Dimples appear on her cheeks when she smiles. range We sell a wide range of goods. a box, bottle, etc. a pot or other object made of clay that has been made permanently hard by Container ceramic heat bowl tea bowl glue a sticky substance that is used for joining things together transform The new bridge will transform the island's tourism industry. emphasize give special importance to something highlight emphasize imperfection a fault or weakness in something a skilled person, especially one who makes beautiful things by hand craftsman specific specific regions of Afirica metallic powder metallic

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