緊急です、！！！！ この反応機構を矢印付きでお願いしたいです、、🥺

21:21 三 46 について | セクション 2.2 NeuroPコアの不斉合成 これ 林ピロリジン触媒存在下での9aの8への有機触媒マイケ ル付加反応とそれに続くアルデヒドの還元は、我々の以 前の報告 [26]と同様に行われ、2段階で89%の収率でアル コール7aが3:1のシン/アンチジアステレオマー混合物と して得られ、シン-7aで86%のee、 アンチ-7aで90%のee であった(図3)。 続いて、 キャンディらの条件下での 酸化Nef反応により、 87%という非常に良好な収率と16:1 のジアステレオマー比で二置換ラクトン11が得られ、 はDBU触媒による熱力学的平衡によってさらに濃縮され た。ラクトンをDIBAL-Hで還元してラクトール6aを得た 後、最初のウィッティヒ反応で開環し、アルコール12を 76%の収率で得た。塩基促進脱離副生成物13の生成を抑 制するために、徹底的な最適化が必要であったことを強 調しておくべきである。 最適化された拡張性と再現性を 備えた条件は、0℃でトルエン中の過剰量のメチル(トリ フェニルホスホニウム) 臭化物から生成したイリドの懸濁 液に6aをゆっくりと制御添加し、その後室温まで昇温す るというものである(詳細は補足情報の表S1およびS2を 参照)。 8 1.A (5mol.%), NO2 P-Nitrophenol (10 mol. %) THF, 15°C, 4 days 2. NaBH4, MeOH, 0 °C, 1 h 89% (two steps), syn/anti 3:1 OPMB 9a *NO2 + HO. HO. OPMB syn-7a anti-7a 86% ee NO2 OPMB 90% ee MePPh3Br, KHMDS Toluene 20°C to rt, 16 h NaNO2 AcOH DMF, 40°C, 16h 1.DBU (20mol.%.) HO THF, r.t., 16 h 2. DIBAL-H Toluene, 87%, trans/cis 16:1 OPMB OPMB 11 -78 to -50°C, 30 min 6a 97% (two steps) HO. HO -OPMB 12 76% スキーム3 13 9% OPMB A Ph Ph OTMS

(4)について This is why にしてしまいました。　 This is becauseというようなThis is whyの表現ではだめな理由を教えてください

(60分) Ⅰ 次の英文を読んで、下の設問 (1)~ (11) の語には注が付いています。 に答えなさい。 なお、 Food is fuel. When your body needs energy, you eat. When it doesn't you don't. It should be so simple when you think about it, but that's exactly the problem: us big smart humans can and do think about it, (, introduces all manner of problems and neuroses*. Have you noticed how you always have "room for dessert"? You might have just eaten the best part of a cow, or enough cheesy pasta to sink a gondola, but you can manage that fudge brownie or sundae. Why? How? If your stomach is full, how ice cream triple-scoop b) eating more even physically possible? It's largely because your brain makes an executive decision and decides that, no, you still have room. The sweetness of desserts is a palpable* reward (7)that the brain recognizes and wants so it overrules the stomach. C Exactly {c case is ③ is 4 the this why) uncertain. It may be that humans need quite a complex diet in order to remain in tip-top* condition, so rather than just relying on our basic metabolic systems to eat whatever is available, the brain steps in and tries to regulate our diet better. And this would be fine if that was all the brain does. But it doesn't. So it isn't. Learned associations are incredibly powerful when it comes ( d ) eating. You may be a big fan of something like, say, cake. You can be eating cake for years without any bother, then one day you eat some cake that makes you vomit. Could be some of the cream in it has gone sour; it might contain an ingredient you're allergic to; or (and here's the annoying one) it could be that something else entirely made you throw up shortly after eating cake. out of The disgust eating poiso g And it consider th The brain than food, it doesn't worryingl needlessl one of li shovelin the brai (注) (1) (2

2段落目の2行目についてです。 和訳を見たところ、ミカル シュワルツの研究に基づいて設立された、とあります。 ここで、"基づいて "は英文中のfound onのことなんでしょうか？

11 脊髄再生医療 英文] 11 It was a miracle of almost biblical proportions. In 1998, scientists in Israel revealed that rats whose spinal cords had been severed had called walked again after an injection of healing immune cells macrophages. Their hopes buoyed by enthusiastic media coverage, = paralysed patients began to dream of taking their own tentative steps. 12 Five years on, the status of those dreams remains unclear. Proneuron Biotechnologies, a Los Angeles-based company founded on the back of the research of lead investigator Michal Schwartz at the Weizmann Institute of Science in Rehovot, is expected soon to release the results of an initial trial of the procedure on eight patients with spinal injuries. Media reports have indicated that some patients have recovered some feeling and movement, but many researchers do not expect a repeat of the rodent miracle. Indeed, they claim that at least one group has since tried, and failed, to reproduce Schwartz's original animal results.

このようなアが指すものを抜き出せみたいな問題はどうやってときますか？

Buyology During an airplane flight, Martin Lindstrom, a marketing expert, read an article about “neuromarketing” in a magazine. Neuromarketing is a new science that studies the brain's responses to advertisements and TV commercials. Neuromarketing looks into why people buy things, using brain scan technology. Lindstrom became so interested in (ア)this new field that he decided to learn more about it. He not only reviewed past studies ( イ ) did research himself. With the help of scientists, Lindstrom scanned the brains of more than 2,000 volunteers from five different countries including Japan. Eventually, he wrote a book on neuromarketing -Buyology.

こうゆうアがさすものを抜き出す問題は前と後ろどちらの文章に答えがありますか？

Buyology During an airplane flight, Martin Lindstrom, a marketing expert, read an article about “neuromarketing” in a magazine. Neuromarketing is a new science that studies the brain's responses to advertisements and TV commercials. Neuromarketing looks into why people buy things, using brain scan technology. Lindstrom became so interested in (ア)this new field that he decided to learn more about it. He not only reviewed past studies ( イ ) did research himself. With the help of scientists, Lindstrom scanned the brains of more than 2,000 volunteers from five different countries including Japan. Eventually, he wrote a book on neuromarketing -Buyology.

英語の現在進行形の問題です 合ってるか教えて頂けると有難いです。

Challenge B Fill in the blanks with the appropriate word(s) to complete the sentences. この日音ん at the moment. 1. The weight scale broke down yesterday ánd is (O being repaired ② having repaired ③ having been repaired © repaired getting a second opinion from another specialist. 2 am thinking of @ think 2. I O am thinking O have thought どうにんな。 3. Todd is normally the quietest in the group, but somehow he talkative now. (@is being のwill be (3) was O has been - 技 4. John is sort of neurotic: he is always going to hospital and diseases. over imaginary Ois worried 2worries worried O worrying

英語 この英文のif以下「私のための研究職がないかどうか」 の「ないかどうか」になる意味がわかりません。 なぜ否定語が無いのに訳は否定になるのですか？

4内容を理解する(B1 ) 下線部(4)a letter「手紙」の内容は,下線部の直後の3の第3文に述べられて いる。I told them のthem はその直前の文にある「スタンフォード大学の神経 科学の教員」を指す。 彼らに宛てた手紙で筆者は,「自分の経歴について」伝え, b ETn ask, know, wonder, see などの 動詞のあとにくるif節は 「~かどう か」という意味を表す名詞節で,動 詞の目的語になっている。 「私のための研究職がないかどうか」を尋ねた。 = the neuroscience faculty members at Stanford University 3 第2文 a letter. I told them {about my background} and asked [if they had a research job for me]. ~第3文 S V1 01 V2 ask if ~「~かどうか尋ねる」 文構造

添削お願いします🙇‍♀️

下記の英文を読んで設問に答えなさい。*の付いている語句に関しては本文の後にまとめて注 があります。 Jason paced the corridor* outside the boardroom* before his presentation. He could heat his pulse (イ) his ears, and his mouth was dry. (1)The last time he felt like this. he told himself to relax. but it didn't work. So this time, he tried something different: "I feel excited." Suddenly, his symptoms* the racing pulse, the twisting stomach, the sweaty palms-started to energize him. The boardroom door opened. He performed brilliantly. This story might be fiction, butat its core lies a very real truth. (2)The science of emotion tells us that our bodies respond( similarly to many different emotions, including anger, excitement and anxiety, And recent research has, shown that if we verbally* put those symptoms into a different context-by saying "I feel excited" when feeling stressed, for example-we can trick ourselves into following suit*. The key to all this is the neurotransmitter*| and hormone norepinephrine*. When you're too stressed or scared, your norepinephrine levels surge* well(ロ)their sweet spot*;/when you tell yourself you're excited,they sometimes fall back. Of course, (3)this trick won't work (ハ) every emotion: it's a lot harder to reframe stress )(ニ) relaxation, because those two conditions have entirely different physical symptoms. Nonetheless, in the right context, stress can become a source of positive energy-not just a by-product* of anxiety. (出典)Ian Robertson, “How Stressing Out Can Help You Succeed", Time, 189 巻,4号,p.15, Jan. 23, 2017. (注) corridor:廊下 boardroom:重役会議室 symptom:症状 verbally: 言葉で neurotransmitter : 神経伝達物質 フリン(興奮を伝達する脳内ホルモンの一種で、ノルアドレナリンとも呼ぶ) surge: 急上昇する、 わき立つ sweet spot : 最適なレベル follow suit:それに従う hormone norepinephrine : ホルモン·ノルエピネ by-product:副産物 彼生が最後にこのように感じたとき、彼失はソラックスするように [設問1] [設問2] 【設問3) [設問4] 下線部(1)を和訳しなさい。 自分に言い開かセたが、 それはりまくいがながった。 下線部(2)を和訳しなさい。 下線部(3)this trickの事例を本文に即して具体的に日本語で説明しなさい。 文中の空欄(イ)~ (=) に入る最も適切な語をそれぞれ次の1から6の中か ら選び番号で答えなさい。 1. after )2(ロ)6. (1)4()ゲ 6. beyond 2. for 3. as 4. * to 5. in (2)情の科学は和たちの体がが怒りや興香,不要すなど、多くの果なる感情に対して、 同じょうに反応することを私たらに伝えている。. (3)身に楽しいいと感じるウに言間けせなと、 1レアドレオリンの分泌量が減ることにより、 ストレスが軽非するということ。

Muto has amyotrophic lateral sclerosis (ALS), a progressive neurological disease[in] which motor nerve cells for controlling voluntary mu... 続きを読む

わからないです

[5 次の英文を読み。 以下の設問に答えよ。 (配点 60点 xtenSiVe を て of your Your dog's ability to learn new tricks may be less a product 7aining (han of ther underlying *genetics ch as aral traits such Among 101 dog *breeds, scientists found that certain behavioral 0 genetically Sirmila 00Gr or Aproasion were more HMI GR PE時昌汗EE 2 S dog behaviors breeds、 While past studies have looked into the genetic foundations of ・the 2ceeg7zzgs の 7@ for certain breeds、thiS research published October 1 in *the /ァの preeds and find a な is the first to investigate a wide diversity of netic signal behavioral aly。 everyone knows that different dogs have 中作erent : の 7ashington in ~ says Noah Snyder-Mackler, a geneticist at the University of Washing Ks の Sa *canines have lived de "But we didnt know how much or why.” Humans and *canine at least 15.000 years. But only within the last 300 years or so have produced Yarieties such as Chihuahuas and Great Danes. Snyder-Mackler and his colleagues considered how 101 dog breeds behave while searching for genetic similarities among breeds sharing certain personality graits. Data came from two dog genotype databases and from C-BARQ, a survey 好at asks owners to rank their pure-bred dog's "propensity for certain behaviors, hike chasing or aggressiveness toward strangers. As a result the study didnt have genetic and behavioral data from the same canine individuals, which could help 岳ghjjght rare genetic varjants that may be nonetheless important to diversity im pehavjors. “Tjeyre not perfect sources of data” says Clive Wynne, an animal behaviorist at Arizona State Unjversity jn Tempe, who was not involved in the study. “But allowed fhem to Jook at ots and lots of dogs.” Using daa from over 14000 dogs described in C-BARQ, the researchers gave each breed a score for 14 different behaviors, and then searched for overall genetic simlarifies among breeds that had similar Scores. For traits such as aggression foward sfrangers, franability and chasing, the researchers found that genes ルー Yo