(x-1)(x+2)(x-3)(x-6)
=(x-1)(x-3)(x+2)(x-6)
=(x^2-4x+3)(x^2-4x-12)
=(x^2-4x)^2-9(x^2-4x)-36
=x^4-8x^3+7x^2+36x-36
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=x^4-8x^3+7x^2+36x-36